Our new Crystal clear+ tissue clearing technique is the only approach that delipidates samples without transform in morphology and with negligible impact on structural integrity.
Megatome is really a vibrating microtome created to area a wide selection of samples, from organoids and biopsy samples to expanded rodent brains and intact human organs. With large blade vibrating frequency and minimized blade deflection, Megatome allows significant-throughput tissue sectioning with uniform area profile, and minimal tissue harm and information loss.
Antibodies might consider weeks to diffuse via only a few millimeters of tissue, having a steep labeling gradient from surface area to core.
Megatome is designed for accuracy: the blade vibrates at a higher frequency and larger amplitude range than other microtomes, and features a unique deflection control mechanism.
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Our preformulated EasyIndex solution raises and homogenize the refractive index of delipidated tissue samples, rendering them absolutely clear. This permits light penetration into the sample and makes sure the acquisition of substantial-resolution, in-target image details.
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It’s time for you to up grade your microtome to Megatome. With correct superior-frequency slicing for an unmatched variety of sample sizes and kinds – from organoids and tumors to expanded tissues, sample arrays, and intact primate organs – Megatome is optimized for numerous programs.
The SmartSPIM light sheet microscope supplies megatomi.com unparalleled resolution and acquisition speed in the course of intact tissue volumes, even though its modular style means that you can update and customize personal components.
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SHIELD avoids the variability of hydrogel embedding and the information reduction from PFA preservation, shielding specimens for multiple rounds of processing.
Leverage the Distinct+ tissue clearing strategy, in conjunction with eFLASH and patented stochastic electrotransport technologies, to quickly very clear and label entire organs. Essential highlights and capabilities include:
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